In the review many body's genes associated with managing colon mucosal honesty, particularly MUC2 (encodes mucin-2), RETNLB (resistin-like beta), TFF2 and TFF3 (trefoil elements Two and three), along with CLDN15 (claudin 16) were down-regulated. Mucin-2 (the main secretory mucin), resistin-like experiment with along with the trefoil proteins are released by goblet tissues [42, 43]. TFF3 is very im